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Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region

They promote insulin secretion only when blood sugar is high, so they are said to have a low risk of hypoglycemia and relatively high safety

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This advantage continued over time, with engaged members seeing 29.1% greater average weight loss at 12 months

Assessing the cardiovascular safety of diabetes therapies

The American Heart Association and the Heart Failure Society of America note that GLP-1R agonists can decrease systemic inflammation and platelet aggregation, contributing to their cardiovascular benefits [101]