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In conclusion, this review indicates that the effects on HR differ within the class of GLP-1 RAs: short-acting GLP-1 RAs are associated with a modest and transient HR increase before returning to baseline levels, while some long-acting GLP-1 RAs are associated with a more pronounced and sustained increase during the day and night

Also, the drug needs to be taken on an empty stomach immediately on waking, with no more than 120 mL of water

While these medications can be highly effective in helping patients lose weight, physicians are also paying close attention to potential side effects, including an increased risk of gallstones.