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Oral semaglutide is the pill form of the drug semaglutide

The following search terms were used: (exenatide OR liraglutide OR albiglutide OR dulaglutide OR lixisenatide OR semaglutide OR tirzepatide OR GLP-1 RAs OR Glucagon-like peptide-1 receptor agonist) AND (acute pancreatitis) AND (case report OR case series)

It may achieve all these effects by stabilizing cholesterol receptors in the liver

Thompson Ray M, Cynthia, Weickert S, Wyatt E, Webster MJ, Ray T, et al

Key evidence points: GLP-1 medications do not directly target or break down muscle tissue Lean mass loss occurs as a consequence of the calorie deficit and weight reduction The proportion of lean mass lost is comparable to other weight loss methods Greater absolute lean mass loss reflects the greater total weight loss achieved Regulatory bodies including NICE and the MHRA have not identified muscle loss as a specific adverse effect requiring special warnings in the Summary of Product Characteristics (SmPCs), though healthcare professionals are advised to monitor nutritional status and encourage appropriate dietary protein intake and physical activity in patients using these medications for weight management

For example, a patient with type 2 diabetes on GLP-1 scheduled for hip replacement may continue the agent until 1 to 2 weeks pre-op if weight loss is modest, but stop earlier if gastroparesis or severe nausea is present