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For those participating in a clinical trial, all adverse effects even those that seem minor should be reported to the trial team as part of the pharmacovigilance process

This evaluation may include reviewing the individuals medical history, current medications, and any potential risks or contraindications for Semaglutide GLP-1 treatment
Additionally, some symptoms resembling hot flashes could potentially be related to other factors

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Cureus, 16 (12), e76139

Understanding this biological reality helps set realistic expectations during the recovery window
