gip and glp-1 New strategies for the treatment of obesity metabolic dysfunctions Biology of Incretins: GLP-1 and
Description
improvement of the lipid profile, inflammation, oxidative stress, endothelial function, and blood pressure

Unfortunately, the physics and biology of the skin make that dream extremely difficult to achieve

Singh P, Vinikoor T, Sharma N, et al

281 Clinical evidence further indicates organ-specific anti-aging effects: semaglutide treatment in individuals with HIV-associated lipohypertrophy resulted in an approximate 3.1-year reduction in biological age, primarily through improvements in the immune/inflammatory system and the brain

Being obese affects the mechanical loading of your joints, and it can initiate or advance the progression of osteoarthritis

That is not failure
