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Volonakis, S

Serious Side Effects Linked to Ozempic While pharmaceutical companies marketed GLP-1 medications as effective treatments for diabetes and weight management, thousands of patients have reported severe adverse effects that allegedly were not adequately disclosed before they began treatment

For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting

Approximately 36% of treatment programs now integrate GLP-1 drugs for dual therapeutic benefits

This is the mechanism most people recognize from medications like Ozempic and Wegovy