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Due to DPP-4 and renal clearance, native GLP-1 in humans has a half-life of about 1-2 minutes (89)

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therefore, GLP-1R agonists may exert beneficial nonglycemic actions partially through modulation of intraepithelial lymphocyte GLP-1R

Kung H-C, Pearson JL, Liu X

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Microtissues (InSphero) formed from 2000 iCell Hepatocytes 2.0 (CDI) were washed and incubated with 10mM lactate, 2M forskolin and a titration of insulin for 6 hours