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Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation

In real-world settings multiple factors contribute to non-persistence, including adverse effects, high cost-sharing and weight loss not meeting patients' expectations.

These medications, primarily prescribed for type 2 diabetes and weight loss, are now at the center of thousands of claims alleging severe gastrointestinal injuries
