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Sexual Side Effects Named in the Petition Decreased capacity to experience sexual pleasure Decreased vaginal lubrication Delayed or absent orgasm Erectile dysfunction Flaccid glans penis during erection Genital anesthesia Loss of libido Persistent genital arousal disorder (PGAD) Pleasureless or weak orgasm Reduced nipple sensitivity Reduced response to sexual stimuli Current labels warn of sexual side effects while taking the drugs but say nothing about the side effects lasting after people discontinue their use

Accessed January 15, 2026 Pharma Voice

Appetite suppression may be mild early on, and some people notice little change at first

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The injection is typically self-administered by the patient at home after an initial in-clinic training session

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