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Treatment of NCI-H716 or STC-1 cells with the Ca 2+ ionophore ionomycin or with phorbol myristate acetate (PMA) increases cytosolic Ca 2+ levels and stimulates GLP-1 secretion in a dose-dependent manner [251,253]

Our findings provide evidence that traditional continuous change from baseline analyses using uncensored data might underestimate disease progression and potentially mask the effects of novel treatments aimed at slowing disease progression

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