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Under cholesterol stimulation, GLP-1-induced AMPK activation inhibited PARP-1 activity, therefore attenuating cholesterol-induced toxicity in INS-1 cells

While semaglutide does not cause UTIs, the medication context helps providers assess overall clinical status, consider potential drug interactions with antibiotics, and evaluate whether gastrointestinal side effects have contributed to dehydration

doi: 10.1007/s00125-022-05722-5 [DOI] [PubMed] [Google Scholar] 25

Discoveries of clinical benefits or their underlying mechanisms are not patentable but may suggest patentable uses or formulations