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Exendin-4 shares approximately 53% structural similarity with human GLP-1 but is resistant to DPP-4 enzyme degradation, giving it a significantly longer half-life than native human GLP-1, which breaks down in approximately 2 minutes

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Positive lipid outcomes have been demonstrated in several of the critical trials that established the cardiovascular benefits of tirzepatide and semaglutide (Table 1

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