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S., GlucagonLike Peptide1 Receptor Agonists Associated Gastrointestinal Adverse Events: A CrossSectional Analysis of the National Institutes of Health all of Us Cohort, Pharmaceuticals 17, no

GLP-1 RAs have shown antitumor effects via metabolic and immune modulation, reduced incidence of obesity-related cancers, and improved outcomes in some patients

Normoglycaemia restoration was more likely to be achieved in the intervention group for liraglutide, semaglutide, and tirzepatide, but not orlistat, compared with placebo (Table 4)

Serious Side Effects (Less Common but Severe) Pancreatitis (inflammation of the pancreas) Gallbladder problems (gallstones) Kidney injury (due to dehydration from severe vomiting or diarrhea) Thyroid tumors (found in animal studies but unclear risk in humans) Hypoglycemia (low blood sugar) Additional Risks with Compounded Semaglutide Since compounded semaglutide lacks FDA approval and its formulation can vary, it may carry extra risks, including: A dose may be stronger or weaker than expected Affecting blood sugar control and weight loss

Its also one of the most common deficiencies in people with higher body weight, even before starting any treatment

Studies show that people lose an average of nearly 21% of their body weight after about two years on the medication