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A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm

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Avoid high-fat meals, fried foods, and greasy dishesfat slows gastric emptying further and compounds GLP-1's slowing effect, intensifying symptoms

These pathways likely contribute to the neuroinflammatory state underlying neuropathic pain

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