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[DOI] [PMC free article] [PubMed] [Google Scholar] 347.Antwi K, et al
Depending on the route of administration (and the GLP-1R agonist used), peripherally administered GLP-1 analogs seem either to act directly in the hypothalamus and hindbrain, both areas with incomplete BBB, or else on vagal afferents to transmit the signal to the hindbrain which then projects to other key feeding areas in the brain
Additionally, Mounjaro , one of the newer diabetes drugs, which was approved in May 2022 and has a unique dual mechanism of action (it activates the GLP-1 hormone as well as another hormone called the glucose-dependent insulinotropic polypeptide or GIP, both helping to improve blood sugar) may be even more effective than semaglutide in reducing weight
However, pharmacokinetic challenges persist
[43] [44] In a 3-year study with people with type 2 diabetes, exenatide showed healthy sustained glucose levels
The performance in the drug group did not change for 24 months in total, while the control group deteriorated continuously and significantly
