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doi: 10.1016/S0140-6736(17)30069-7 25 Pi-SunyerXAstrupAFujiokaKGreenwayFHalpernAKrempfMet al
In the TRIUMPH-1 trial, the 4 mg dose had a lower discontinuation rate due to adverse events than even placebo, suggesting that lower doses are well-tolerated
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Furthermore, LDLR gene expression can be increased by both SREBP-2-dependent and AMPK-dependent mechanisms
