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N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

KDIGO clinical practice guideline for lipid management in CKD: summary of recommendation statements and clinical approach to the patient

[DOI] [PMC free article] [PubMed] [Google Scholar] [82].Rinaman L

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Maintaining regular physical activity, social engagement, and sleep hygiene helps distinguish treatment-related mood changes from other contributing factors

However, key preclinical studies in mice indicate otherwise