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Pioglitazone stabilizes the clusters of this redox-active iron-sulfur protein at the MERCS, preventing deleterious ultrastructural changes and protecting against the lipid peroxidation that drives hepatic steatosis (Paddock et al., 2007

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It is very similar to a natural hormone in the body called GLP-1

Sensitivity tests Before PSM, the analysis of the crude populations showed consistent findings, indicating that GLP-1RA plus SGLT2i was associated with the primary composite outcome and individual outcomes compared to SGLT2i alone (Supplementary Table 4)