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Its design is based on the sequence of a natural glucose-dependent insulinotropic polypeptide (GIP) and simultaneously activates the glucagon-like peptide-1 (GLP-1) receptor, hence the name "twincretin." The drug first entered clinical research in 2016, with Eli Lilly initiating a Phase I clinical trial to evaluate its safety, tolerability, pharmacokinetics, and pharmacodynamics in obese or overweight subjects with related comorbidities

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They may also order lab tests before recommending tirzepatide or another treatment

Who May Be at Higher Risk and When Tirzepatide Might Not Be Right Tirzepatide is not appropriate for every person seeking weight loss support

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