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Across the 52 weeks of ATTAIN-MAINTAIN, participants treated with orforglipron gained an average of 5 kg (11 lbs) in the tirzpatide group and an average of 1 kg (2.2 lbs) in the semaglutide group

[DOI] [PubMed] [Google Scholar] 50.Opazo-Rios L, et al
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Increasing the dose may produce additional weight loss, but it also increases side effects and cost

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