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GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes

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demonstrated that GLP1-R activation leads to a modest but statistically significant increase in cAMP concentration in mixed leucocyte populations, including Tregs ( Figure 1 )

In a Phase 2 trial of 62 patients with moderate Parkinsons disease, once-weekly exenatide produced a motor advantage in the off-medication state that persisted twelve weeks after the drug was stopped, which the authors interpreted as a possible signal of disease modification rather than symptomatic relief [6]

10.1002/oby.24229 7 DaniilopoulouI.VlachouE.LambrouG