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Even though GLP-1 RAs mimic a natural hormone in the body, they do have some potential GI side effects, including constipation, which appears to be more common than diarrhea in patients who reach out to Oshi Health for help

Storage Guidelines for Retatrutide Pens

Gastric emptying slows within 48-72 hours of injection, and satiety hormone (GLP-1 and PYY) elevation persists 5-7 days, explaining weekly dosing effectiveness

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Insulin doses typically require reduction of 20 to 50 percent when starting tirzepatide to prevent hypoglycemia

Choosing between a medication that increases heart rate and blood pressure versus one that reduces MACE events by 20 percent is not a close call when cardiovascular health is a concern
