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Additional clinical manifestations of the aging hand include textural roughness, dyschromia, lentigines, seborrheic and/or actinic keratosis, and wrinkling.[58] Traditional treatments to rejuvenate aged hands include lasers, intense light sources, chemical peels, sclerotherapy, dermal fillers/fat augmentation, and topical skin care products.[610] Sodium copper chlorophyllin complex (CHLcu) has been shown to have several therapeutic properties in vitro, including antioxidant, anti-inflammatory, and antibacterial properties and inhibition of hyaluronidase.[1115] In addition, topical application of very low concentrations of this active ingredient (0.0250.1%) has been shown to have clinically beneficial effects on facial photodamage, redness, enlarged pores, and acne.[1618] Recently, in a human biopsy study, CHLcu demonstrated the ability to repair photodamaged skin by stimulation of biomarkers in the human extracellular matrix.[19] A topical formulation of liposomal CHLcu, urea, lipids, antioxidants, and humectants has been developed as a treatment to enhance skin texture, moisturize, and improve skin barrier function and signs of photodamaged skin

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