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GLP-1 receptor agonist 4 can be used in the research for treatment of diabetes
Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule
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In addition, it is likely that TCF7L2 functions as a modulator of vascular GLP-1 receptor expression.
