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GLP-1Rs are expressed on glial cells (77, 78), which allows GLP-1RAs to exert direct antiinflammatory effects

In these specific cases the first study is selecting a subject cohort based on a diagnosis of diabetes mellitus type 2 (DMT2) and the second obesity

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We then used each model to select the 50 best sequences for each of the three target designs defined above, and selected the ten most diverse sequences as starting points for a second round of optimization