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is supported, in part, by a Banting and Best Diabetes CentreNovo Nordisk Chair in Incretin Biology, a Sinai HealthNovo Nordisk Foundation Fund in Regulatory Peptides, CIHR grants 154321 and 19204 and Diabetes Canada-Canadian Cancer Society grant (OG-3- 24-5819-DD)

J Clin Gastroenterol

One concern about GLP-1 medicines had been whether they were associated with an increase in risk of suicide or suicidal thoughts, prompting European regulators to open an investigation into the issue in 2023

On the basis of several putative modes of action under investigation (for example, neuroprotective and anti-inflammatory properties, regulation of reward pathways), there is an emerging consensus that GLP-1RAs could be repurposed for use in neuropsychiatric conditions 25,26,27,28,29,30,31,32

Primary research articles were prioritized where available, particularly for mechanistic and translational claims

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