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The National Institute for Health and Care Excellence (NICE) guideline NG28 recognises both drug classes as treatment options within the type 2 diabetes management pathway
[PMCID:PMC11043712]
Tirzepatide differs from semaglutide in its combined GLP-1 agonist and glucose-dependent insulinotropic polypeptide (GIP) agonist action
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2025;24(2):e16716
Furthermore, SP can directly inhibit insulin-dependent glucose metabolism in rat adipocytes (81)
