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Currently, certain manufacturers have established production systems in strict compliance with the GMP standards of both China's NMPA and the U.S

However, improvement in the brain is limited by the presence of the bloodbrain barrier (BBB), a selectively permeable barrier between the capillaries and the brain that prevents the efficient transfer of high molecular weight therapeutic drugs from the blood to the brain parenchyma and thus hinders effective treatment of MPS with CNS involvement

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USPSTF, United States Preventive Service Task Force

Both medications affect metabolic pathways, insulin sensitivity, and body composition differently, making provider oversight essential before any combination is considered