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While the two medications are similar in this way, they differ in others

Scale changes during this phase average two to four pounds for most patients

So far, no significant hypoglycaemia signal has been seen, likely because GLP-1 and GIP agonism counterbalance glucagons glucose-raising effect, but this remains an area of ongoing surveillance

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Two deaths (unrelated to the treatment) were reported in semaglutide group [61]