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Liraglutide (Figure 1D), dulaglutide (Figure 1E), semaglutide (Figure 1F), and tirzepatide (Figure 1H), which incorporate fatty acid conjugation using a linker or an IgG fragment crystallizable (Fc) region, display minimal renal clearance and prolonged half-lives (Figure 2CG).60 Detailed information on their pharmacokinetic characteristics is provided below

Noteworthy, hyperglycemia induces the synthesis of AT1R, which plays a pivotal role in reno- and cardiovascular disease

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doi: 10.1016/j.ejca.2008.07.040

Available from: Accessed 1 Mar 2023 Brown E, Heerspink HJL, Cuthbertson DJ, Wilding JPH (2021) SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications