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The oral formulation is the most significant differentiator: if an oral tablet can produce weight loss comparable to injectable CagriSema, it could fundamentally change how dual pathway obesity therapy is delivered

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The lack of follow-up of neonates born to women exposed to either GLP-1 agonists or SGLT2 inhibitors is a barrier to the study of potential adverse effects only apparent later in life

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414 Together, these effects contribute to the protection of dopaminergic neurons (source)