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Ethics statement The animal studies were approved by the 1

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BMJ 29(372):n71 Crocker TF, Lam N, Jordo M, Brundle C, Prescott M, Forster A et al (2023) Risk-of-bias assessment using Cochranes revised tool for randomized trials (RoB 2) was useful but challenging and resource-intensive: observations from a systematic review

However, challenges include higher costs and limited long-term safety data, necessitating further studies to confirm its cardiovascular benefits in non-diabetic populations and cerebrovascular conditions, such as vascular dementia [15]

Most patients report increased shedding about 3 to 6 months after beginning GLP-1 therapy

Interestingly, several studies have demonstrated that exendin-4 has neurotrophic and neuroprotective effects and that it enhances neurogenesis and neural proliferation (Li et al., 2009