fda drug safety communication naion semaglutide 2025 The NAION signal observed with semaglutide continues to generate GLP-1 Overdoses Are Rising as
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Even if expired semaglutide does not appear spoiled, these invisible chemical changes mean it may no longer deliver the expected therapeutic dose
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The composition of GLP-1 prescribing changed markedly over the period

The mean changes from baseline to week 26 were -0.9 kg and -3.4 kg in the placebo and RYBELSUS 14 mg arms, respectively