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In NOD mice, treatment with the DPP4 inhibitor MK0431 prolonged the survival of islet grafts and reduced CD4+ T cell migration into the pancreas through the cAMP/PKA/Rac1 activation pathway

The drug helps regulate blood sugar levels while also promoting weight loss, both of which are critical for people with type 2 diabetes

evaluated 25 RCTs and observational studies of GLP-1 RA in patients with type 2 diabetes up to 2012

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More recent studies have reported that complex factors, such as infection, environmental exposures, diabetes and metabolic disorders, and genetics, may all contribute to dementia risk
