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NICE guidance recommends tirzepatide at a BMI 35 kg/m 2 with one weight-related co-morbidity, but the NHS in England is not likely to meet that goal for another 12 years, with a much more restrictive initial criteria of a BMI 40 kg/m 2 and four out of a list of five co-morbidities

3,4 This receptor and its agonists hold significant therapeutic potential, reshaping the treatment approaches for multiple diseases, including diabetes, cardiovascular disorders, and neurodegenerative diseases

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