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Dietary approaches offer significant advantages

10.1001/jama.2021.23619 [DOI] [PMC free article] [PubMed] [Google Scholar] 66

These include: New formulations and delivery mechanisms Lower dose, high bioavailability innovations Blood brain barrier (BBB) penetrating designs New modalities such as ADCs and fusion proteins Routine FTO checks, composition and combination filings, and route of administration strategies will be essential to maintain advantage

There is a relative lack of prospective or randomised clinical studies in cohorts of PDM on specific interventions, such as advanced strategies to optimise enzyme replacement therapy, emerging insulin delivery systems or dual incretin agonists

Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, et al

How often to take FDA-approved oral GLP-1 tablets Once a day