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This is non-negotiable based on current evidence

2013;5:209ra151

Norgaard RA, Bhatt DK, Jarvinen E, et al

GIPR adipo/ mice showed significant reductions in interleukin-6 (IL-6) mRNA expression in adipocytes, blood IL-6 levels, triglyceride accumulation in the liver, and systemic insulin resistance [104]

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