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The study analyzed fasting plasma samples obtained from two previously conducted phase 2 randomized controlled trials (RCTs)

Critical limitations include: Heterogeneity : Different strains, doses, and formulations make comparisons difficult Small effect sizes : Weight changes are typically modest and may not be clinically significant Short duration : Most studies last 12 weeks or less, providing no data on sustained effects Publication bias : Negative studies may be underreported There is no high-quality evidence that probiotic supplements can replicate the substantial weight loss achieved with prescription medications like semaglutide or tirzepatide

doi: 10.1038/s41591-024-03095-3

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Os resultados divulgados at agora so considerados dados iniciais, conhecidos como topline, que representam uma anlise preliminar dos principais achados