berberine glp 1 agonist compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice Weight loss meds or glp-1

Modulation of gut microbiota Recent research suggests that GLP-1 receptor agonists significantly affect the composition of gut microbiota, revealing a new mechanism that contributes to metabolic advantages (Liang et al

Due to high costs and limited availability, some patients are turning to social media sites and online clinics to obtain GLP-1 receptor agonist medications

Finding: This meta-analysis demonstrates that perioperative GLP-1RAs increased the rate of GI symptoms and the risk of elevated residual gastric content, improved glycemic control, and did not change the rates of hypo or hyperglycemia, postoperative inotropic support, PONV, atrial fibrillation, and 30-day mortality

This is a medical emergency that requires immediate attention

doi:10.1016/j.biopha.2018.08.088 199

GLP-1 RAs may provide additional therapeutic benefits beyond glycemic control due to their multifaceted metabolic and anti-inflammatory properties