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NIT-1 cells treated with PA+Ex-4 and PA+GW showed enhanced GSIS capacity, increased PPAR expression, decreased UCP2 expression and ADP/ATP ratio, and improved mitochondrial DNA content and mitochondrial membrane potential compared with those treated with PA alone, whereas the opposite results were observed in the PA+GSK group

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Evidence-based comparison of exenatide (Byetta/Bydureon) and liraglutide (Victoza/Saxenda), including the LEAD-6 head-to-head trial, DURATION vs SCALE data, and the evolution from exendin-4-based to human GLP-1-based analogs.

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