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The reset may spark faster-than-expected price erosion across the GLP-1 segment, even before widespread generic entry, industry insiders told ET

38 There have been four previous randomized control trials in IIH 12,4042 and one prospective crossover trial

Average total body weight loss (TBWL) after one year on a GLP-1 semaglutide such as Wegovy and Ozempic is 12%15%, and on a GLP-1 tirzepatide like Mounjaro, & Zepbound is 21%

Sarcopenic obesity, which combines obesity and sarcopenia, is concerning and is associated with reduced quality of life and elevated risk of falls, cardiovascular disease, and mortality

For instance, in the pivotal SURPASS-2 trial, patients receiving the highest tirzepatide dose (15 mg) achieved a mean body weight reduction of 11.2 kg, nearly twice that observed with semaglutide 1 mg (5.7 kg) (19)

Combining GLP-1 receptor agonists with structured lifestyle changes, especially increased protein intake and strength training, can mitigate muscle loss and enhance overall outcomes
