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We walk through what the data actually showed, why the comparison was misleading, how trial design and dosing matter, and why Phase 1 results should never be treated as superiority claims

This recommendation does not reflect proven harm but rather the principle that medications should only be used during lactation when benefits clearly outweigh theoretical risks

Thus, sacubitril monotherapy was not satisfactory and valsartan is used to block undesirable RAAS activation (168)

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