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A general guideline is to aim for a calorie deficit that promotes a healthy rate of weight loss

GLP-1RAs delay gastric emptying, which slows nutrient absorption and stabilizes glucose levels after meals [7]

GI side effects are common: nausea, reduced appetite beyond what's useful, occasional digestive disruption

In contrast, AOM semaglutide increased by +0.1 points from June to Julyits largest one-month gain in the study period, compared with an average of just +0.02 points per month previously

For anyone with hypertension or cardiovascular risk, semaglutide is the safer choice by a wide margin