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Emerging research on GLP-1 medications covers fatty liver, kidney disease, sleep apnoea, PCOS, and neurodegeneration

In a study using cultured rat hippocampal neurons, pre-treatment of nerve cells with GLP-1 resulted in a weakened Ca 2+ response to glutamate and weakened membrane depolarization ( Effects on Parkinsons Disease Parkinsons disease (PD) is a chronic neurodegenerative disease that affects the central nervous system and the second most common neurodegenerative disease after AD (56)

Even more telling is that a substantial number of individualsfrom 20.7% to 68.4%lost more than 10% of their initial body weight

Constipation tends to worsen with dose titration and stabilize after several weeks at a maintenance dose

The extended-release formulation maintains therapeutic levels exceeding 50 pg/mL from approximately 2 weeks post-injection, complicating perioperative timing decisions [28]

Though these drugs have been deemed effective in treating T2DM, the Food and Drug Administration (FDA) and some members of the scientific community have questioned the safety of these therapeutics relative to important cardiovascular endpoints