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Larger, extended studies would be helpful in ascertaining whether benefits of earlier use of metformin, such as benefits in reducing cardiovascular risk demonstrated among those with diabetes in the UK Prospective Diabetes Study ( Implementing paradigm shifts in general obesity management into psychiatry As in general overweight and obesity management, heterogeneity in response to any intervention is to be expected ( Statements Author contributions IF: Conceptualization, Investigation, Project administration, Visualization, Writing original draft, Writing review & editing
