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Description
Contact your GP or diabetes specialist if you experience : Persistent vomiting that prevents you from keeping down food, fluids, or other medications for more than 24 hours Signs of dehydration , including dark urine, dizziness, extreme thirst, dry mouth, or reduced urination Abdominal pain , particularly if constant, sharp, or radiating to your back (potential pancreatitis) Nausea that significantly worsens rather than improves over time Inability to maintain adequate nutrition or unintended weight loss exceeding clinical targets Symptoms of hypoglycaemia (low blood sugar) if taking Ozempic alongside insulin or sulphonylureasshakiness, confusion, sweating, rapid heartbeat [1] [4] Right upper abdominal pain, fever, or yellowing of skin/eyes , which could indicate gallbladder disease (a known risk with GLP-1 receptor agonists) Seek immediate medical attention (call 999 or attend A&E) if you develop : Severe, persistent abdominal pain with vomiting (possible pancreatitis) Signs of allergic reactionfacial swelling, difficulty breathing, severe rash Symptoms of diabetic ketoacidosisexcessive thirst, frequent urination, confusion, fruity-smelling breath (particularly relevant if you use insulin or during intercurrent illness

N Engl J Med 2021;384:117128 [DOI] [PubMed] [Google Scholar] 82

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In addition to the risk of low blood sugar, drinking alcohol while on tirzepatide may increase other side effects, such as nausea or upset stomach

Few controlled trials do offer positive results though

According to the SmPC, these include: Nausea usually mild to moderate and often diminishing over time Vomiting and diarrhoea which can contribute to dehydration if not managed appropriately Abdominal pain and decreased appetite reflecting the medication's effect on gastric emptying and satiety signals Constipation affecting some patients, particularly those with reduced food and fluid intake Severe gastrointestinal symptoms can lead to dehydration, which may precipitate acute kidney injury in some patients
