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Bruising after semaglutide shots is a common concern for patients using this glucagon-like peptide-1 (GLP-1) receptor agonist for type 2 diabetes or chronic weight management

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Particles can come from: Degraded peptide forming insoluble aggregates Contamination during manufacturing or storage Rubber stopper fragments from repeated needle punctures Crystallization of dissolved components If you see particles, do not try to filter them out