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Rapid weight loss itself can contribute to musculoskeletal discomfort as the body adapts to changes in biomechanics, muscle mass, and joint loading patterns

The complex pathophysiology and the metabolic risk factors shared between type 2 diabetes, obesity, CKD and cardiovascular disease have led to the concept of a cardiovascularkidneymetabolic (CKM) syndrome

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The refrigerated shelf life of tirzepatide follows similar patterns, and the degradation mechanisms are comparable though not identical

Another study noted similar side effects, including nausea (38.1%), vomiting (9.5%), abdominal distention (4.8%), and diarrhea (4.8%)

Patients should be advised to report any suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app)