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At tissue level, RAS (renin-angiotensin system) can be upregulated with non-hemodynamic effects (35)
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But the clinical trial data tells a very different story than what Reddit and TikTok would have you believe
Indications of increased vertebral fracture risk in patients with type 2 diabetes
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GLP-1 receptor activation slows gastric emptying, which can lead to constipation in certain individuals
