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Sitagliptin, the first developed inhibitor, has a triazolopiperazine structure, while vildagliptin and saxagliptin have a cyanopyrrolidine structure

Tirzepatide: dual receptor, amplified effects Tirzepatide activates both GLP-1 and GIP receptors simultaneously

Nbel J, Truthmann J, Heidemann C, Du Y, Paprott R, Hapke U, et al

Our study aims to evaluate the association between the use of GLP-1 RAs, considered as a single class, and the risk of pancreatitis in a comorbidity-free subgroup of patients with type 2 diabetes mellitus (T2DM) in the United States

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30%) [Figure I]
